炎症結腸靶向抗氧化劑納米療法——一種有效的炎症性腸病治療方法

韓國成均館大學的科學家團隊使用炎症結腸靶向抗氧化納米療法（ICANs）在結腸炎中調節原位氧化應激水平。ICANs由介孔二氧化矽納米顆粒（MSNs）和表面附着的活性氧（ROS）清除的铈納米顆粒（CeNPs）組成，它們進一步被聚丙烯酸（PAA）包裹，通過靜電相互作用優先粘附到炎症的結腸組織。通過優化分子量和PAA塗層pH，獲得了較高的ROS清除特性，即使在人工胃腸液體孵育後仍然有效。在右旋糖酐硫酸鈉誘導的IBD急性炎症小鼠模型中，口服ICANs顯示出對炎症結腸組織的粘附增強。相關研究成果于2023年12月1日發表在 ACS Nano期刊，突顯了無創性ICANs作爲通過氧化應激水平調節結腸炎治療炎性腸道疾病的一種有前途的候選藥物的潛力。

Dong Kwang Min, Ye Eun Kim, Min Kyung Kim, et al.（School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea）

ACS Nano, Vol 17, (23)24404-24416

Inflammatory bowel disease (IBD) is characterized by an inappropriate and persistent inflammatory immune response and is often accompanied by excessive reactive oxygen species (ROS) production. For effective IBD treatment, there is a high demand for safe and targeted therapy that can be orally administered. In this study, we aimed to propose the use of inflamed colon-targeted antioxidant nanotherapeutics (ICANs) for in situ oxidative stress level modulation in colitis. ICANs consist of mesoporous silica nanoparticles (MSNs) with surface-attached ROS-scavenging ceria nanoparticles (CeNPs), which are further coated with poly(acrylic acid) (PAA) to facilitate preferential adherence to inflamed colon tissues through electrostatic interaction. We achieved a high ROS-scavenging property that remained effective even after artificial gastrointestinal fluid incubation by optimization of the molecular weight and PAA-coating pH. The orally administered ICANs demonstrated enhanced adherence to inflamed colon tissues in an acute inflammation mouse model of IBD induced by dextran sulfate sodium. This targeted delivery resulted in gut microenvironment modulation by regulating redox balance and reducing inflammatory cell infiltration, thereby suppressing the colitis-associated immune response. These findings highlight the potential of noninvasive ICANs as a promising candidate for treating inflammatory intestinal diseases by oxidative stress level modulation in colitis.